{"id":45145,"date":"2026-03-12T12:35:13","date_gmt":"2026-03-12T11:35:13","guid":{"rendered":"https:\/\/nightwatchepilepsy.com\/?page_id=45145"},"modified":"2026-09-16T13:28:27","modified_gmt":"2026-09-16T12:28:27","slug":"scientific-evidence","status":"publish","type":"page","link":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/","title":{"rendered":"Scientific evidence"},"content":{"rendered":"\n<div class=\"et_pb_section_0 et_pb_section et_section_regular et_block_section preset--module--divi-section--default\" id=\"NWResearch\"><div class=\"et_pb_row_0 et_pb_row et_block_row\"><div class=\"et_pb_column_0 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_text_0 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><div id=\"comp-ka5fcqsf\" class=\"_1Q9if\" data-testid=\"richTextElement\">\n<h1 class=\"font_2\"><span>Scientific evidence<\/span><\/h1>\n<\/div>\n<\/div><\/div><\/div><\/div><div class=\"et_pb_row_1 et_pb_row et_block_row\"><div class=\"et_pb_column_1 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_text_1 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><h2><strong>Research<\/strong><\/h2>\n<p>NightWatch+ originates from decades of conjoined research by the Dutch TeleEpilepsy consortium.<\/p>\n<\/div><\/div><div class=\"et_pb_image_0 et_pb_image et_pb_module et_block_module\"><span class=\"et_pb_image_wrap\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/12\/NightWatch_timeline_US.jpg\" width=\"2305\" height=\"769\" srcset=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/12\/NightWatch_timeline_US.jpg 2305w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/12\/NightWatch_timeline_US-1280x427.jpg 1280w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/12\/NightWatch_timeline_US-980x327.jpg 980w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/12\/NightWatch_timeline_US-480x160.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 2305px, 100vw\" class=\"wp-image-43996\" title=\"NightWatch_timeline_US\" \/><\/span><\/div><div class=\"et_pb_text_2 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><p>Most nocturnal seizures go unrecognized by caregivers. NightWatch is designed to support people with epilepsy and their caregivers by providing reliable seizure monitoring during nighttime hours, when supervision can be challenging and stressful. Our focus is on detecting seizure types associated with increased risk of morbidity and mortality that may require immediate assistance, including:<\/p>\n<p><span><\/span><\/p>\n<ul>\n<li>Tonic-clonic seizures (TC)<\/li>\n<li>Tonic seizures (if clustered or prolonged &gt;30 seconds)<\/li>\n<li>Hyperkinetic seizures<\/li>\n<li>TC-like seizures<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><div class=\"et_pb_section_1 et_pb_section et_section_regular et_block_section preset--module--divi-section--default\"><div class=\"et_pb_row_2 et_pb_row et_block_row\"><div class=\"et_pb_column_2 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_image_1 et_pb_image et_pb_module et_block_module\"><span class=\"et_pb_image_wrap\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/NW-2Pager\/NightWatch_Multimodal_EN.jpg\" width=\"1073\" height=\"897\" srcset=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/NW-2Pager\/NightWatch_Multimodal_EN.jpg 1073w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/NW-2Pager\/NightWatch_Multimodal_EN-980x819.jpg 980w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/NW-2Pager\/NightWatch_Multimodal_EN-480x401.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1073px, 100vw\" class=\"wp-image-41395\" title=\"NightWatch+_Multimodal_EN\" \/><\/span><\/div><div class=\"et_pb_text_3 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><p><strong>Multimodal Seizure Detection<br \/><\/strong>NightWatch detects nocturnal epileptic motor seizures by tracking changes in heart rate and specific movement patterns through a wearable sensor. It uses advanced PPG for heart rate tracking and a 3D accelerometer for body position and movement. The detection algorithm is optimized using long-term data from adults and children (&gt; 4 years of age) with thousands of nighttime seizures, validated against video recordings as the reference standard.<\/p>\n<\/div><\/div><\/div><\/div><div class=\"et_pb_row_3 et_pb_row et_block_row\"><div class=\"et_pb_column_3 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_text_4 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><p><strong>Validated Detection Performance<br \/><\/strong>NightWatch's detection performance has been validated through multiple multicenter trials in realistic home settings. The studies demonstrated for children (4-16 years of age) mean sensitivities of 90% for all major motor seizure types and 98% for tonic-clonic seizures. The mean false alarm rate was 0.07 per hour, and the median was 0.04 per hour, meaning that most users experienced 1 false alarm every 3-4 nights. The false alarm rates varied widely among users, and many of the false alarms were, in fact, minor seizures that did not qualify as major (dangerous) nocturnal motor seizures.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"et_pb_section_2 et_pb_section et_section_regular et_block_section preset--module--divi-section--default\" id=\"NWPublications\"><div class=\"et_pb_row_4 et_pb_row et_block_row\"><div class=\"et_pb_column_4 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_text_5 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><div id=\"comp-ka5fcqsf\" class=\"_1Q9if\" data-testid=\"richTextElement\">\n<h1 class=\"font_2\"><span>Publications<\/span><\/h1>\n<\/div>\n<\/div><\/div><\/div><\/div><div class=\"et_pb_row_5 et_pb_row et_block_row\"><div class=\"et_pb_column_5 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_text_6 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><h2><strong>Key publication<\/strong><\/h2>\n<\/div><\/div><div class=\"et_pb_image_2 et_pb_image et_pb_module et_block_module\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.17654\" target=\"_blank\"><span class=\"et_pb_image_wrap\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Epilepsia-2023_EN.png\" width=\"1920\" height=\"850\" srcset=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Epilepsia-2023_EN.png 1920w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Epilepsia-2023_EN-1280x567.png 1280w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Epilepsia-2023_EN-980x434.png 980w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Epilepsia-2023_EN-480x213.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 1920px, 100vw\" class=\"wp-image-41791\" title=\"NightWatch_Epilepsia-2023_EN\" \/><\/span><\/a><\/div><div class=\"et_pb_text_7 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><h2><strong>Other publications<\/strong><\/h2>\n<\/div><\/div><div class=\"et_pb_image_3 et_pb_image et_pb_module et_block_module\"><a href=\"https:\/\/www.seizure-journal.com\/article\/S1059-1311(22)00182-0\/fulltext\" target=\"_blank\"><span class=\"et_pb_image_wrap\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Seizure-2022_EN.png\" width=\"1920\" height=\"850\" srcset=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Seizure-2022_EN.png 1920w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Seizure-2022_EN-1280x567.png 1280w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Seizure-2022_EN-980x434.png 980w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Seizure-2022_EN-480x213.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 1920px, 100vw\" class=\"wp-image-41767\" title=\"NightWatch_Seizure-2022_EN\" \/><\/span><\/a><\/div><div class=\"et_pb_image_4 et_pb_image et_pb_module et_block_module\"><a href=\"https:\/\/n.neurology.org\/content\/91\/21\/e2010\" target=\"_blank\"><span class=\"et_pb_image_wrap\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Neurology-2018_EN.png\" width=\"1920\" height=\"850\" srcset=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Neurology-2018_EN.png 1920w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Neurology-2018_EN-1280x567.png 1280w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Neurology-2018_EN-980x434.png 980w, https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/04\/NightWatch_Neurology-2018_EN-480x213.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 1920px, 100vw\" class=\"wp-image-41743\" title=\"NightWatch_Neurology-2018_EN\" \/><\/span><\/a><\/div><\/div><\/div><div class=\"et_pb_row_6 et_pb_row et_block_row\"><div class=\"et_pb_column_6 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_module et_pb_button_module_wrapper et_pb_button_0_wrapper preset--module--divi-button--default_wrapper\"><a class=\"et_pb_button_0 et_pb_button et_pb_bg_layout_light et_pb_module et_block_module preset--module--divi-button--default\" href=\"\/nightwatch_summary-clinical-evidence_us\/\" target=\"_blank\">A summary of the clinical evidence of NightWatch<\/a><\/div><\/div><\/div><\/div><div class=\"et_pb_section_3 et_pb_section et_section_regular et_block_section preset--module--divi-section--default\"><div class=\"et_pb_row_7 et_pb_row et_block_row\"><div class=\"et_pb_column_7 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_text_8 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><h2><strong>Other relevant publications on NightWatch or its working principles<\/strong><\/h2>\n<\/div><\/div><div class=\"et_pb_text_9 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><ul type=\"disc\">\n<li class=\"m_-6463297226673146810MsoListParagraph\"><span>Zelano, J., Beniczky, S., Ryvlin, P., Surges, R., Tomson, T., &amp; the ILAE SUDEP Task Force. (2023). Report of the ILAE SUDEP Task Force on national recommendations and practices around the world regarding the use of wearable seizure detection devices: A global survey.\u00a0<\/span><span lang=\"DE\">Epilepsia Open.<\/span> <a class=\"epub-doi\" aria-label=\"Digital Object Identifier\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi4.12801\" target=\"_blank\" rel=\"noopener\">doi.org\/10.1002\/epi4.12801<\/a><span><br \/>\n<strong>Summary:<br \/>\n<\/strong><\/span><span lang=\"EN-GB\">The article<span>\u00a0<\/span><i>\"Report of the ILAE SUDEP Task Force on national recommendations and practices around the world regarding the use of wearable seizure detection devices\"<\/i><span>\u00a0<\/span>examines global recommendations and practices concerning the use of wearable devices for seizure detection. It highlights the importance of these technologies in monitoring seizures and their potential to enhance patient safety. The article mentions that NightWatch has been clinically tested in the Netherlands and is used in epilepsy care. The device has contributed to increased patient safety and improved nighttime monitoring.<\/span><span lang=\"EN-GB\"><\/span><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\">Hadady L, Kliv\u00e9nyi P, Fab\u00f3 D, Beniczky S. Real-world user experience with seizure detection wearable devices in the home environment. Epilepsia. 2022;00:1\u20136. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.17189\" target=\"_blank\" rel=\"noopener\">doi: 10.1111\/epi.17189<\/a><br \/>\n<strong>Summary:<\/strong><br \/>\nThe article examines the practical usability and effectiveness of wearable seizure detection devices in a home setting. It highlights the general feasibility and benefits of automated seizure detection at home, which can contribute to improved monitoring and safety for patients with epilepsy.<\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\"><span lang=\"NL\">van Elmpt WJC, Nijsen TME, Griep PAM, Arends JBAM.<span>\u00a0<\/span><\/span>A model of heart rate changes to detect seizures in severe epilepsy. Seizure. 2006;15(6):366\u201375. <a href=\"https:\/\/www.seizure-journal.com\/article\/S1059-1311(06)00059-8\/fulltext\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.seizure.2006.03.005<\/a><br \/>\n<strong>Summary:<\/strong><br \/>\n<span>The article explores using heart rate changes to detect seizures in patients with severe epilepsy. It developed two algorithms to monitor heart rate patterns, identifying significant changes like tachycardia and bradycardia during seizures. The study found that heart rate changes occurred in most patients. It concluded that heart rate changes can be used for automatic seizure detection, provided the model parameters are tailored to individual patients.<\/span><br \/>\n<u><\/u><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\">Mass\u00e9 F, Penders J, Serteyn A, van Bussel M, Arends J. Miniaturized wireless ECG-monitor for real-time detection of epileptic seizures. WH\u201910. 2010 Oct; 111-117. <a href=\"https:\/\/dl.acm.org\/doi\/10.1145\/1921081.1921095\" target=\"_blank\" rel=\"noopener\">doi: 10.1145\/1921081.1921095<\/a><br \/>\n<strong>Summary:<\/strong><br \/>\n<span>The article highlights the feasibility of using heart rate changes as indicators for seizure activity, offering a non-invasive method for monitoring patients with epilepsy.<\/span><br \/>\n<u><\/u><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\">Lamberts RJ, Thijs RD, Laffan A, Langan Y, Sander JW. Sudden unexpected death in epilepsy: People with nocturnal seizures may be at highest risk: Nocturnal Seizures as a Risk for SUDEP. Epilepsia. 2012;53(2):253\u20137.<span>\u00a0<\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1528-1167.2011.03360.x\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/doi.org\/10.1111\/j.1528-1167.2011.03360.x&amp;source=gmail&amp;ust=1690363743695000&amp;usg=AOvVaw1nG1qdYaKcSot2fBwGZb6Z\" rel=\"noopener\">doi: 10.1111\/j.1528-1167.2011.03360.x<\/a><br \/>\n<strong>Summary:<\/strong><br \/>\n<span>The article investigates the association between nocturnal seizures and the risk of sudden unexpected death in epilepsy (SUDEP). The study suggests that individuals experiencing seizures during sleep may have an increased risk of SUDEP. These findings underscore the importance of preventive measures, which may include nighttime monitoring and interventions to reduce seizure frequency during sleep.<\/span><br \/>\n<u><\/u><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\">van Andel J, Leijten F, van Delden H, van Thiel G (2015) What Makes a Good Home-Based Nocturnal Seizure Detector? A Value Sensitive Design. PLoS ONE 10(4): e0121446. <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0121446\" target=\"_blank\" rel=\"noopener\">doi: 10.1371\/journal.pone.0121446<\/a><br \/>\n<strong>Summary:<\/strong><br \/>\n<span>The study investigates the development of a device for in-home detection of nocturnal seizures in patients with severe epilepsy. It identifies five key values: health, trust, autonomy, accessibility, and reliability. These values were then linked to design choices for the device.<\/span><br \/>\n<u><\/u><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\"><span lang=\"NL\">Arends JB, van Dorp J, van Hoek D, Kramer N, van Mierlo P, van der Vorst D, et al.<span>\u00a0<\/span><\/span>Diagnostic accuracy of audio-based seizure detection in patients with severe epilepsy and an intellectual disability. Epilepsy Behav. 2016;62:180\u20135.<span>\u00a0<\/span><a href=\"https:\/\/www.epilepsybehavior.com\/article\/S1525-5050(16)30163-9\/fulltext\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/doi.org\/10.1016\/j.yebeh.2016.06.008&amp;source=gmail&amp;ust=1690363743695000&amp;usg=AOvVaw3OAUOwCFDRSqsmb3iijObq\" rel=\"noopener\">doi: 10.1016\/j.yebeh.2016.06.008<\/a><br \/>\n<strong>Summary:<\/strong><br \/>\n<span>The study evaluates the use of audio monitoring for detecting major seizures in patients with severe epilepsy. It suggests that audio-based detection could be used alone or in combination with other systems for better seizure monitoring.<\/span><br \/>\n<u><\/u><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\">van Andel J, Thijs RD, de Weerd A, Arends J, Leijten F. Non-EEG based ambulatory seizure detection designed for home use: What is available and how will it influence epilepsy care? Epilepsy Behav. 2016;57:82\u20139.<span>\u00a0<\/span><a href=\"https:\/\/www.epilepsybehavior.com\/article\/S1525-5050(16)00009-3\/fulltext\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/doi.org\/10.1016\/j.yebeh.2016.01.003&amp;source=gmail&amp;ust=1690363743695000&amp;usg=AOvVaw3FI3I8IcCvp7QhZM6Hz4Ku\" rel=\"noopener\">doi: 10.1016\/j.yebeh.2016.01.003<\/a><br \/>\n<span><strong>Summary:<\/strong><br \/>\nThe article reviews existing non-EEG seizure detection systems suitable for home use. It evaluates various devices and algorithms, discussing their potential impact on epilepsy management. The study emphasizes the importance of these technologies in enhancing patient safety and monitoring outside clinical settings.<\/span><br \/>\n<u><\/u><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\">van der Lende M, Cox FME, Visser GH, Sander JW, Thijs RD. Value of video monitoring for nocturnal seizure detection in a residential setting. Epilepsia. 2016;57(11):1748\u201353.<span>\u00a0<\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13558\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/doi.org\/10.1111\/epi.13558&amp;source=gmail&amp;ust=1690363743695000&amp;usg=AOvVaw3slfP1bdVG-soRKJiCxHGG\" rel=\"noopener\">doi: 10.1111\/epi.13558<\/a><br \/>\n<strong>Summary:<\/strong><br \/>\n<span>Conducted in a residential care facility, the research found that video Monitoring significantly increased the identification of seizures requiring clinical intervention. <\/span><span>The study concluded that Video monitoring is a valuable tool for enhancing patient safety and improving the management of nocturnal seizures in such settings.<\/span><br \/>\n<u><\/u><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\"><span lang=\"NL\">van Andel J, Ungureanu C, Arends J, Tan F, Van Dijk J, Petkov G, et al.<span>\u00a0<\/span><\/span>Multimodal, automated detection of nocturnal motor seizures at home: Is a reliable seizure detector feasible? Epilepsia Open. 2017;2(4):424\u201331.<span>\u00a0<\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi4.12076\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/doi.org\/10.1002\/epi4.12076&amp;source=gmail&amp;ust=1690363743695000&amp;usg=AOvVaw2ej_qbMcrv6ui2aEK-o9My\" rel=\"noopener\">doi: 10.1002\/epi4.12076<\/a><br \/>\n<strong>Summary:<\/strong><br \/>\n<span>The study investigates the feasibility of using non-electroencephalographic (non-EEG) signals\u2014specifically heart rate and accelerometry\u2014to detect various types of nocturnal seizures, including tonic, tonic-clonic, hypermotor, and clusters of short myoclonic\/tonic seizures. The research involved monitoring patients during diagnostic video-EEG examinations. The findings suggest that automated seizure detection using these non-EEG signals is feasible and could enhance patient safety by enabling timely interventions.<\/span><br \/>\n<u><\/u><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\"><span lang=\"NL\">Geertsema EE, Thijs RD, Gutter T, Vledder B, Arends JB, Leijten FS, et al.<span>\u00a0<\/span><\/span>Automated video-based detection of nocturnal convulsive seizures in a residential care setting. Epilepsia. 2018;59:53\u201360.<span>\u00a0<\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.14050\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/doi.org\/10.1111\/epi.14050&amp;source=gmail&amp;ust=1690363743695000&amp;usg=AOvVaw3srFeooG_7Dw3P2c_TY6IT\" rel=\"noopener\">doi: 10.1111\/epi.14050<\/a><br \/>\n<strong>Summary:<\/strong><br \/>\n<span>The study evaluates the effectiveness of a video-based algorithm for detecting nocturnal convulsive seizures in individuals with epilepsy residing in a care facility. <\/span><span>The algorithm analyzes group velocity signals derived from video sequences to identify seizures. The study concludes that this automated system is effective for real-time seizure detection in residential care settings, potentially enhancing patient safety.<\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><div class=\"et_pb_section_4 et_pb_section et_section_regular et_block_section preset--module--divi-section--default\" id=\"PublicationsListNightWatch\"><div class=\"et_pb_row_8 et_pb_row et_block_row\"><div class=\"et_pb_column_8 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_text_10 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><h2 class=\"font_2\"><span>Cited literature<\/span><\/h2>\n<\/div><\/div><\/div><\/div><div class=\"et_pb_row_9 et_pb_row et_block_row\"><div class=\"et_pb_column_9 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\"><div class=\"et_pb_text_11 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module ordered-list\"><div class=\"et_pb_text_inner\"><ol>\n<li><span lang=\"NL\">Arends J, Thijs RD, Gutter T, Ungureanu C, Cluitmans P, van Dijk J, et al.<span>\u00a0<\/span><\/span>Multimodal nocturnal seizure detection in a residential care setting: A long-term prospective trial, Neurology. 2018 Nov 20; 91(21):e2010-e2019. <a href=\"https:\/\/n.neurology.org\/content\/91\/21\/e2010\" target=\"_blank\" rel=\"noopener\">doi: 10.1212\/WNL.0000000000006545<\/a><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\">Beniczky S, Wiebe S, Jeppesen J, Tatum WO, Brazdil M, Wang Y, et al. Automated seizure detection using wearable devices: A clinical practice guideline of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology. Epilepsia. 2021 Mar; 62(3):632-646. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1388245720306143?via%3Dihub\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.clinph.2020.12.009<\/a>.<u><\/u><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\"><span lang=\"NL\">Lazeron RHC, Thijs RD, Arends J, Gutter T, Cluitmans P, van Dijk J, et al.<span>\u00a0<\/span><\/span>Multimodal nocturnal seizure detection: Do we need to adapt algorithms for children? Epilepsia. 2022; 7(3):406\u201313. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi4.12618\" target=\"_blank\" rel=\"noopener\">doi: 10.1002\/epi4.12618<\/a><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\">van Westrhenen A, Lazeron RHC, van Dijk JP, Leijten FSS, Thijs RD, the Dutch TeleEpilepsy Consortium. Multimodal nocturnal seizure detection in children with epilepsy: A prospective, multicenter, long\u2010term, in\u2010home trial. Epilepsia. 2023. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.17654\" target=\"_blank\" rel=\"noopener\">doi: 10.1111\/epi.17654<\/a><u><\/u><\/li>\n<li class=\"m_-6463297226673146810MsoListParagraph\"><span lang=\"NL\">Engelgeer A, van Westrhenen A, Thijs RD, Evers SMAA.<span>\u00a0<\/span><\/span>An economic evaluation of the NightWatch for children with refractory epilepsy: Insight into the cost-effectiveness and cost-utility. Seizure. 2022;101:156\u201361. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36030593\/\" target=\"_blank\" rel=\"noopener\">doi: 10.1016\/j.seizure.2022.08.003<\/a><\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":45020,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-45145","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Scientific evidence of NightWatch+<\/title>\n<meta name=\"description\" content=\"NightWatch+ originates from decades of conjoined research by the Dutch TeleEpilepsy consortium.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientific evidence of NightWatch+\" \/>\n<meta property=\"og:description\" content=\"NightWatch+ originates from decades of conjoined research by the Dutch TeleEpilepsy consortium.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/\" \/>\n<meta property=\"og:site_name\" content=\"NightWatch\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/EpilepsySeizureDetectionEN\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-16T12:28:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/02\/NightWatch_Multimodal_Detection-1024x760.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2023\/07\/NightWatch_clinical-research-1024x882.png\" \/>\n<meta name=\"twitter:site\" content=\"@NightWatchAlarm\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/scientific-evidence\\\/\",\"url\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/scientific-evidence\\\/\",\"name\":\"Scientific evidence of NightWatch+\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/scientific-evidence\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/scientific-evidence\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/NW_arm-module_light-shadow_small.png\",\"datePublished\":\"2026-03-12T11:35:13+00:00\",\"dateModified\":\"2026-09-16T12:28:27+00:00\",\"description\":\"NightWatch+ originates from decades of conjoined research by the Dutch TeleEpilepsy consortium.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/scientific-evidence\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/scientific-evidence\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/scientific-evidence\\\/#primaryimage\",\"url\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/NW_arm-module_light-shadow_small.png\",\"contentUrl\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/NW_arm-module_light-shadow_small.png\",\"width\":720,\"height\":720},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/scientific-evidence\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scientific evidence\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/#website\",\"url\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/\",\"name\":\"NightWatch\",\"description\":\"Epilepsy seizure detection | Warns during sleep\",\"publisher\":{\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/#organization\",\"name\":\"NightWatch Epilepsy Seizure Detection\",\"alternateName\":\"NightWatch\",\"url\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/NightWatch-Logo.png\",\"contentUrl\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/NightWatch-Logo.png\",\"width\":696,\"height\":696,\"caption\":\"NightWatch Epilepsy Seizure Detection\"},\"image\":{\"@id\":\"https:\\\/\\\/nightwatchepilepsy.com\\\/en-us\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/EpilepsySeizureDetectionEN\",\"https:\\\/\\\/x.com\\\/NightWatchAlarm\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/nightwatch-epilepsy-detection\\\/\",\"https:\\\/\\\/www.instagram.com\\\/nightwatch_epilepsie_detectie\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Scientific evidence of NightWatch+","description":"NightWatch+ originates from decades of conjoined research by the Dutch TeleEpilepsy consortium.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/","og_locale":"en_US","og_type":"article","og_title":"Scientific evidence of NightWatch+","og_description":"NightWatch+ originates from decades of conjoined research by the Dutch TeleEpilepsy consortium.","og_url":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/","og_site_name":"NightWatch","article_publisher":"https:\/\/www.facebook.com\/EpilepsySeizureDetectionEN","article_modified_time":"2026-09-16T12:28:27+00:00","og_image":[{"url":"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/02\/NightWatch_Multimodal_Detection-1024x760.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_image":"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2023\/07\/NightWatch_clinical-research-1024x882.png","twitter_site":"@NightWatchAlarm","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/","url":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/","name":"Scientific evidence of NightWatch+","isPartOf":{"@id":"https:\/\/nightwatchepilepsy.com\/en-us\/#website"},"primaryImageOfPage":{"@id":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/#primaryimage"},"image":{"@id":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/#primaryimage"},"thumbnailUrl":"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/02\/NW_arm-module_light-shadow_small.png","datePublished":"2026-03-12T11:35:13+00:00","dateModified":"2026-09-16T12:28:27+00:00","description":"NightWatch+ originates from decades of conjoined research by the Dutch TeleEpilepsy consortium.","breadcrumb":{"@id":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/#primaryimage","url":"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/02\/NW_arm-module_light-shadow_small.png","contentUrl":"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2025\/02\/NW_arm-module_light-shadow_small.png","width":720,"height":720},{"@type":"BreadcrumbList","@id":"https:\/\/nightwatchepilepsy.com\/en-us\/scientific-evidence\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/nightwatchepilepsy.com\/en-us\/"},{"@type":"ListItem","position":2,"name":"Scientific evidence"}]},{"@type":"WebSite","@id":"https:\/\/nightwatchepilepsy.com\/en-us\/#website","url":"https:\/\/nightwatchepilepsy.com\/en-us\/","name":"NightWatch","description":"Epilepsy seizure detection | Warns during sleep","publisher":{"@id":"https:\/\/nightwatchepilepsy.com\/en-us\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nightwatchepilepsy.com\/en-us\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nightwatchepilepsy.com\/en-us\/#organization","name":"NightWatch Epilepsy Seizure Detection","alternateName":"NightWatch","url":"https:\/\/nightwatchepilepsy.com\/en-us\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nightwatchepilepsy.com\/en-us\/#\/schema\/logo\/image\/","url":"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2023\/02\/NightWatch-Logo.png","contentUrl":"https:\/\/nightwatchepilepsy.com\/wp-content\/uploads\/2023\/02\/NightWatch-Logo.png","width":696,"height":696,"caption":"NightWatch Epilepsy Seizure Detection"},"image":{"@id":"https:\/\/nightwatchepilepsy.com\/en-us\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/EpilepsySeizureDetectionEN","https:\/\/x.com\/NightWatchAlarm","https:\/\/www.linkedin.com\/company\/nightwatch-epilepsy-detection\/","https:\/\/www.instagram.com\/nightwatch_epilepsie_detectie\/"]}]}},"_links":{"self":[{"href":"https:\/\/nightwatchepilepsy.com\/en-us\/wp-json\/wp\/v2\/pages\/45145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nightwatchepilepsy.com\/en-us\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nightwatchepilepsy.com\/en-us\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nightwatchepilepsy.com\/en-us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nightwatchepilepsy.com\/en-us\/wp-json\/wp\/v2\/comments?post=45145"}],"version-history":[{"count":10,"href":"https:\/\/nightwatchepilepsy.com\/en-us\/wp-json\/wp\/v2\/pages\/45145\/revisions"}],"predecessor-version":[{"id":48240,"href":"https:\/\/nightwatchepilepsy.com\/en-us\/wp-json\/wp\/v2\/pages\/45145\/revisions\/48240"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nightwatchepilepsy.com\/en-us\/wp-json\/wp\/v2\/media\/45020"}],"wp:attachment":[{"href":"https:\/\/nightwatchepilepsy.com\/en-us\/wp-json\/wp\/v2\/media?parent=45145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}